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Clinical utility of genomics in non-Hodgkin lymphoma

Clinical utility of genomics in non-Hodgkin lymphoma

Background

Melbourne Genomics’ Clinical Flagships have been at the forefront of determining when genomic testing makes a demonstrable difference to the safety and quality of patient care.

Non-Hodgkin lymphoma (NHL) is one of 16 areas of health investigated by Melbourne Genomics. It is the most common form of blood cancer in Australia and the sixth most common cancer overall. About 90% of lymphoma is non-Hodgkin – the focus of this project.

Even with the best available treatment, up to half of patients with high-risk advanced NHL will die of the disease.

Advanced NHL is among the most diverse cancers: in terms of the number of different genomic variants present in one type of cancer and the number of contributory variants within an individual’s cancer.

Project description

The objective: to determine the feasibility of providing genomic testing to improve management of advanced NHL if and when a patient relapses.

The Advanced Non-Hodgkin Lymphoma Flagship was led by Professor Stephen Opat (Monash Health) and Professor Miles Prince (Peter MacCallum Cancer Centre), with Dr Gareth Gregory (Monash Health) providing key coordination. Thirty health professionals were directly involved.

Activities, outcomes and lessons learnt

Findings from this project will be made available following publication of results.

Impact

The Flagship enabled one of the hospital sites to implement and develop professional capacity in interpreting WES for lymphoma.

This project facilitated development of critical infrastructure and expertise through shared knowledge and experience.

Clinical Flagship team




Name

Organisation

Role

Stephen Opat

Monash Health

Haematologist

Miles Prince

PeterMac

Haematologist

Gareth Gregory

Monash Health

Haematologist

Abhijit Kulkarni

Monash Health

Cytogeneticist

Alison Trainer

PeterMac

Clinical geneticist

Andrew Grigg

Austin Health

Haematologist

Asif Alam

Monash Health

Molecular scientist

Beena Kumar

Monash Health

Anatomical pathologist

Eliza Hawkes

Austin Health

Oncologist

Geoff Chong

Austin Health

Oncologist

George Grigoriadis

Monash Health

Haematologist

Georgina Ryland

PeterMac

Molecular scientist

Greg Corboy

Monash Health

Molecular haematopathologist

Jake Shortt

Monash Health

Haematologist

Joel Wight

RMH

Haematology fellow

Jonathan Wong

Monash Health

Haematology fellow

Josh Casan

Monash Health

Haematology fellow

Kay Weng Choy

Monash Health

Clinical biochemistry fellow

Kylie Mason

RMH

Haematologist

Matthew Hunter

Monash Health

Clinical geneticist

Matthew Regan

Monash Health

Clinical genetics fellow

Michael Dickinson

PeterMac

Haematologist

Niro Pathirage

Monash Health Translation Precinct

Molecular scientist

Paul Defazio

Monash Health

Variant curation scientist

Piers Blombery

PeterMac

Molecular haematopathologist

Ricky Johnstone

PeterMac

A/Director, Laboratory Research

Tania Cushion

Austin Health

Clinical nurse consultant

Trevor Wilson

Monash Health Translation Precinct

Molecular scientist

Vivien Vasic

Monash Health Translation Precinct

Platform & Medical Genomics Facility Manager

Wishva Herath

Monash Health

Clinical bioinformatician

Yael Prawer

Monash Health

Genetic counsellor